ABSTRACT


Antisense OligoNucleotide (AON) and Allele-Specific oligonucleotide (ASO) technologies are amongst the most important approaches for the sequence-specific knockdown of gene expression. AON & ASO have been used as research tools in the post-genome era, as well as new types of therapeutic agents. Since finding effective target sites within RNA is a hard work for antisense AON design, various experimental methods and computational approaches have been proposed.

Skip-E, is a bioinformatics system built to assist researchers in selecting the best region of interest to design Antisense Oligonucleotide (AON) to induce exon skipping. It can be used to restore a functional protein or silence a gene. AON & ASO have been used as research tools in the post-genome era, as well as new types of therapeutic agents.

For better sharing of the experimented and published efficient or inifficient AON, literature reports are regularly screened, collected and stored. Till now, approximately 350 AON & ASO targeting 90 mRNAs/gene/exon are contained in the AonDBase. Users can check whether their AON & ASO have already been reported. To add an AON/ASO, please send us information to enrich the database.

Skip-E and the AonDBase are freely available for non-commercial users. Nevertheless it is not allowed to copy all or part of the database content without specific authorisation from us. If you are a commercial user please contact us to obtain a dedicated license. For more information please contact Prof. Christophe BĂ©roud or Dr. David Salgado

LINKS


FUNDINGS